Principal Product Manager

Principal Product Manager
Position Summary

Natera is at the forefront of personalized genetic testing, transforming the management of disease worldwide. As we scale our life-saving diagnostics, we are fundamentally transforming how software products are conceived, built, and delivered across our clinical and genomic portfolio.

We are seeking an experienced Principal Digital Product Manager to join our Oncology Comprehensive Genomic Profiling (CGP) Product Engineering team. In this senior individual contributor role, you will serve as the product lead for our most complex platform initiatives — owning end-to-end product strategy and execution across a sophisticated system of interconnected software products.

You will act as the product backbone for our most critical "Pillar" projects. Success in this role demands mastery from three dimensions: partnership with commercial teams to define product strategy/roadmap based on market needs; deep fluency in how end users - lab operations, clinical teams, customer success teams - actually work; and close collaboration with Engineering, R&D, and PMO on product design and delivery. You will synthesize all three into product decisions that hold up end-to-end — from order ingestion through lab execution to patient reporting — ultimately delivering reliable, high-quality solutions that patient care depends on.

Crucially, while this is an individual contributor role, you will operate as a central leader — driving consensus, roadmap alignment, and product excellence through influence rather than formal authority across Engineering, R&D, Commercial, and Clinical teams. You thrive in fluid environments, adapt quickly to change, and chart a clear path forward even amid unknowns.
Key Responsibilities
Strategic Leadership & Vision

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Define Long-Term Vision: Develop and execute multi-year software product roadmaps for critical business units, balancing rapid prototyping with long-term commercial stability.

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Architect Complex Solutions: Act as a high-level Architect, translating broad business goals into detailed functional workflows. You are accountable for the cohesion and integrity of the final end-to-end solution.

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Founder's Mindset: Champion a culture of high agency and urgency, making quick, data-driven decisions in ambiguous situations to deliver critical milestones in a fast-paced environment.

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Cross-Functional Influence: Lead by expertise rather than authority, aligning stakeholders across R&D, Engineering, Operations, Quality, and Regulatory to ensure the software roadmap meets broader business goals.

Product Excellence & Execution

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End-to-End Ownership: Lead the full product lifecycle for complex software solutions, ensuring a seamless user journey across various system boundaries — from order ingestion through lab execution to patient reporting.

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Technical Translation: Serve as the primary domain expert, translating complex scientific, clinical, or technical requirements into robust, scalable software specifications.

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Operational Immersion: Passionately advocate for internal and external users by regularly shadowing operations and engaging with customers to ensure software solves real-world physical and clinical problems.

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Systems Thinking: Maintain a "big picture" view of how software systems interact across the entire data lifecycle, understanding how upstream decisions ripple through to downstream clinical and reporting outcomes.

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Agile Mastery: Lead with the rigor of a seasoned project manager, owning product backlogs and driving Agile ceremonies to ensure timely delivery of high-quality features.

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AI-Native Product Development: Pioneer the use of LLMs and generative AI tools to accelerate product discovery, automate requirements synthesis, and continuously improve how we deliver value to users.

Regulatory & Quality Leadership

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Compliance Champion: Partner with Quality and Regulatory teams to ensure all products comply with releva