Executive Director, Clinical Operations

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME , a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.
Why Join Us?

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Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

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Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

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Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Position Summary

The Executive Director, Clinical Operations serves as the operational deputy and strategic partner to the VP, Clinical Operations. This high-impact executive role provides integrated leadership across the entire clinical operations ecosystem. You will translate high-level clinical strategy into seamless portfolio delivery, scalable organizational capability, and robust global execution. As a systems-builder and visionary leader, you will run today’s global clinical portfolio with operational excellence while simultaneously building the capabilities required for tomorrow's late-stage development and commercialization.

Location: Global (US / Germany; Remote)
Reports To: Vice President, Clinical Operations
Salary Range: $270,000 to $300,000
Basic Qualifications:

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Bachelor’s degree in a scientific, nursing, or business discipline required;

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15+ years of clinical research experience within a biotech, pharmaceutical, or major CRO environment, including 7+ years in a senior, multi-functional leadership capacity.

Preferred Qualifications:

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Advanced degree (MD, PhD, PharmD, MS, or MBA) preferred.

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Direct operational experience managing Cell Therapy, Immuno-Oncology, or advanced therapeutic modality trials is a strong plus.

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Directly manage and inspire a geographically dispersed, multicultural clinical operations teams, with specific focus on harmonizing workflows between US and European (Germany) team members. A natural "systems builder" who thrives on creating infrastructure, optimizing workflows, and designing scalable processes. Demonstrated track record of leading multiple dimensions of clinical operations (e.g., trial management, data/systems, sample logistics, site monitoring).

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Extensive experience leading complex, global clinical trials across North America and Europe (experience with US/Germany structures is highly desirable). Deep experience navigating clinical operations in Oncology is required.

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Proven experience driving Phase III registrational trials, global regulatory filings (BLA/NDA/MAA submissions), and preparing operations for commercialization.

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Demonstrated experience leading Clinical Operations within a biopharmaceutical organization with strong understanding of internal clinical operations, trial execution and regulatory requirements.

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Sophisticated experience managing large-scale CRO partnerships and vendor governance committees.

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Strong communication and influencing skills, with the clear capability

Key Responsibilities
1. Integrated Clinical Operations Leadership

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Operational Deputy: Lead day-to-day operations of the global Clinical Operations organization on behalf of the VP; serve as primary delegate and decision-maker within established authority matrices.

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Functional Integration: Align functional teams to ensure Trial/Asset Operations, Site Operations, Biosample Operations, and Clinical Systems function as one unified, high-performing ecosystem.

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Strategic Alignment: Bridge the gap between corporate development milestones and operational realities, aligning all sub-functions toward shared portfolio timelines.

2. Portfolio Execution & Operational Oversight

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Portfolio-Wide Visibility: Maintain an