Medical Director / Senior Medical Director
Position: Medical Director / Senior Medical Director
Department: Clinical Development
Location: Remote with up to 20% domestic travel
Reports To: Executive Director, Clinical Development
Position Summary
Angitia Biopharmaceuticals is seeking a highly motivated, organized, and entrepreneurial-minded Medical Director or Senior Medical Director to provide clinical development leadership for global programs in rare musculoskeletal diseases. This role combines strategic clinical development responsibilities with hands-on study execution and medical oversight in a lean, science-driven biotechnology environment.
The successful candidate will serve as Clinical Development Team Lead for key development programs and provide medical oversight for ongoing global clinical trials. The position requires a physician who is scientifically rigorous, highly detail-oriented, and willing to operate across both strategic and operational aspects of clinical development, including medical monitoring, study conduct, protocol execution, review of study-level documents, and cross-functional team leadership.
The ideal candidate will bring strong clinical judgment, exceptional attention to detail, and a passion for advancing therapies for patients with rare diseases. Prior industry experience or substantial direct experience with industry-sponsored clinical trials is preferred. The successful candidate should be familiar with, or able to rapidly adopt, rigorous clinical development processes, including protocol governance, cross-functional document review, regulatory documentation standards, inspection readiness, and disciplined study execution in a fast-paced, growing biotechnology environment.
Responsibilities
Medical Monitoring and Clinical Oversight
- Serve as internal Medical Monitor and/or provide oversight of medical monitoring activities for ongoing studies
- Ensure study activities are conducted in accordance with established clinical development governance processes, quality standards, regulatory requirements, and inspection-ready documentation practices.
- Review subject eligibility, protocol deviations, adverse events, serious adverse events, laboratory abnormalities, and emerging study data.
- Participate in safety review meetings and support interactions with Data Monitoring Committees and regulatory authorities.
- Provide medical guidance to investigators and study sites.
Clinical Development Team (CDT) Leadership
- Serve as Clinical Development Team Lead for assigned development programs in rare bone disease
- Provide clinical leadership and oversight for ongoing global phase 2 clinical studies and future late phase clinical planning
- Lead cross-functional Clinical Development Teams and partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Clinical Pharmacology, Data Management, and Research.
- Contribute to overall clinical development strategy, lifecycle planning, and regulatory interactions.
Study Execution and Operational Excellence
- Ensure high-quality clinical trial conduct across global studies.
- Draft, author, review and/or approve study protocols, study manuals, monitoring plans, charters, investigator training materials, informed consent documents, clinical study reports, and other study-level documentation with close attention to consistency, completeness, and operational feasibility.
- Drive high-quality development of study and regulatory documents, ensuring consistency across protocols, manuals, charters, statistical analysis plans, investigator materials, clinical study reports, and regulatory submissions.
- Collaborate with Clinical operations, CROs, internal study teams to ensure operational excellence and inspection readiness.
- Drive resolution of study conduct, enrollment, data quality, and protocol implementation issues.
External Engagement
- Support interactions with regulatory agencies, investigators, and key opinion leaders.
- Represent the comp