Information System Security Officer (ISSO) (R-00183)
True Zero Technologies , a veteran-owned small business, was founded on the principle that the purposeful enablement of people and technology in an organization directly ties to the quality of its outcomes. True Zero recognizes that those outcomes begin and end with our people, and that is what we have built a community of like-minded, driven, and passionate individuals and innovators who are aligned in a common goal of delivering top-tier services to our customers. Our culture and commitment have been recognized through numerous accolades, including being named one of the Best Places to Work in 2023 in two categories (“Prosperous and Thriving” ($5MM–$50MM in gross revenue) and “Mid-Atlantic Region” (DC, DE, MD, NC, VA, WV)), and again in 2025 as a Best Places to Work honoree. In addition, True Zero earned coveted spots on the Inc. 5000 list of fastest-growing companies in America in 2022, 2023, and 2025 , a testament to our sustained growth driven by our people-first approach and unwavering dedication to excellence.
True Zero is seeking an Information System Security Officer (ISSO) to support cybersecurity governance and Risk Management Framework (RMF) activities for enterprise information systems at the National Institutes of Health (NIH). Working under the direction of the Senior ISSO, this position partners with System Owners, engineers, cybersecurity operations personnel, and Government stakeholders to maintain the security posture and authorization readiness of assigned systems.
The ISSO is responsible for coordinating the day to day execution of RMF activities, maintaining security documentation, supporting continuous monitoring, tracking remediation efforts, and ensuring cybersecurity activities remain aligned with Federal requirements throughout the system lifecycle. This role requires strong organizational skills and the ability to coordinate activities across multiple technical disciplines while serving as a trusted advisor to system stakeholders.
Job Responsibilities
- Support assigned information systems through all phases of the Risk Management Framework (RMF) lifecycle.
- Maintain System Security Plans (SSPs), security documentation, and authorization artifacts to accurately reflect the operational environment.
- Coordinate with System Owners to ensure security requirements are incorporated into system operations and lifecycle activities.
- Collect, organize, and validate evidence supporting security control implementation and continuous monitoring activities.
- Track vulnerabilities, POA&Ms, remediation activities, risk acceptance decisions, and corrective actions to ensure timely resolution and accurate documentation.
- Coordinate with vulnerability management, penetration testing, and incident response teams to ensure cybersecurity findings are incorporated into authorization documentation and continuous monitoring activities.
- Support annual assessments, Security Control Assessments (SCAs), audits, and authorization reviews by coordinating evidence collection, documentation updates, and stakeholder participation.
- Monitor system changes to identify potential impacts to authorization status and coordinate required documentation updates.
- Assist with contingency planning, incident response planning, interconnection security agreements, privacy documentation, and other required cybersecurity artifacts.
- Prepare recurring authorization status reports, remediation updates, and security summaries for Government stakeholders.
- Participate in change management, configuration management, governance meetings, and continuous monitoring activities to ensure cybersecurity considerations remain integrated into operational decision making.
- Coordinate closely with engineering teams to ensure security controls are properly implemented and documented.
- Support continuous improvement initiatives that strengthen authorization quality, improve documentation accuracy, and enhance operational efficiency.